how does glutathione s-transferase cause drug resistance in cancer cells Unveiling the Role of Protein Breast Resistance: Insights into the Signaling Pathways and Therapeutic Implications The Different Mechanisms of Cancer

We recently discovered that many human plasma proteins are also specifically converted into chaperone-like holdases by N-chlorination and as such, gain the ability to protect other proteins from HOCl-induced aggregation [37]

While distinct from glutathione, these pathways work together

Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype

demonstrated in patients with advanced colorectal cancer treated by either anti-EGFR inhibition or without, the expression of autophagy proteins Beclin-1 and LC3 were not only associated with advanced colorectal cancer, but those with higher expression of these proteins experienced worse objective response rates, and shorter progression free survival

De la Fuente M, Hernanz A, Guayerbas N (2008) Vitamin E ingestion improves several immune functions in elderly men and women