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Current perspective regarding the immunopathogenesis of drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS)

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The X-box-binding protein-1 (XBP1), spliced and activated by IRE1, is downregulated in glomerular mesangial cells, weakening the inhibitory effect on the phosphatase and tensin homolog (PTEN)/Akt pathway, thereby aggravating kidney damage