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This is the central mechanism most reviews focus on

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How Topical Administration Works in Research Protocols Topical GHK-Cu dosing uses concentration-based dosing rather than absolute-mass dosing

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Key facts from Pickarts original studies: GHK-Cu exists in the plasma of all healthy adults The concentration decreases with age , from ~200 ng/ml in 20-year-olds to ~80 ng/ml in 60-year-olds This decline correlates with the age-related loss of regenerative capacity of tissue Cu is essential for the biological activity, GHK without copper has a dramatically weaker effect These original observations launched a 50-year research program that today covers thousands of publications in dermatology, wound healing, ageing research and regenerative medicine