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One study has hypothesized that excess folic acid causes the body to redirect holoTC (the active form of B12) from the bloodstream to bone marrow, where it supports the rapid growth of new red blood cells

Tbx1 is only expressed in a subset of brain vessels (1.5% of brain cells) in the adult mouse (24), but it excludes significant noncell-autonomous transcriptional effects on the brain parenchyma