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RPMI-1640, minimum essential medium, foetal bovine serum (FBS), non-essential amino acids, geneticin G418, gentamicin, L-glutamine, penicillin/streptomycin, sterile Hepes buffer, sterile cell culture sodium bicarbonate, ethylenediaminetetraacetic acid, 10 trypsin- ethylenediaminetetraacetic acid solution, TMZ, ammonium formate, indium tin oxide-coated glass slides, dry dichloromethane, deuterated chloroform (CDCl 3 ) and sterile dimethyl sulfoxide were purchased from Sigma Aldrich (Dorset, UK)

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