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As diabetes is associated with alterations in the microbial profiles and reduced diversity, microbiome may contribute to the severity and progression of the disease (Vrieze et al., 2012

PMID: 56 BieriSMllerBAmslerJ

The Effects of Long-Term Oral Benfotiamine Supplementation on Peripheral Nerve Function and Inflammatory Markers in Patients With Type 1 Diabetes: A 24-month, double-blind, randomized, placebo-controlled trial

Here, we have utilized liver-specific overexpression of cation transport regulator homolog 1 ( Chac1 ), a recently identified intracellular GSH-degrading enzyme, to induce hepatic GSH depletion during MASLD progression

(PubMed) Pledgie-Tracy A, Sobolewski MD, Davidson NE