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of Biomedicine and Prevention, 2 Dept

Evolution of NADPH oxidase inhibitors: selectivity and mechanisms for target engagement

Insulin resistance, associated with mitochondrial dysfunction and increased production of ROS, alters the cardiovascular, renal, and neural functions of insulin and is a risk factor for microvascular disease

Lephart ED

These essential processes help shape appropriate cellular responses at infection sites but are also responsible for dysregulated activation of systemic inflammation and are potentially harmful to the host