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Presumably, the combination of ROS accumulation with a COVID-19-specific hypoxia triggered a shift to anaerobic glycolysis, which is a primary factor driving immunometabolic dysfunction in CD8 lymphocytes during SARS-CoV-2 infection

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doi: 10.1021/ja808018y 295 ColeAJYangVCDavidAE

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In breast cancer, the newly identified circVDAC3 confers resistance to trastuzumab by preventing the ubiquitination of HSPB1, reducing ferroptosis 721 (Fig