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Y., Song, X., Brown, E

SR: Validation, Writing review & editing, Supervision, Conceptualization

Howard SC, McCormick J, Pui C-H, Buddington RK, Harvey RD (2016) Preventing and managing toxicities of high-dose methotrexate

The ratio of 18 O incorporation was measured by HPLCMS and calculated as the ratio of peak areas of selected ion monitoring of the [M] + ions

A classic pharmacokinetic study in the Annals of Internal Medicine (Levine et al., 2004) found that a modeled 50 g IV dose produced peak plasma levels around 13,400 mol/L, versus 220 mol/L for the maximum tolerated oral regimen roughly 3070 times higher plasma concentrations with IV administration