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The study demonstrated that lactic acid produced by glycolytically active tumor cells induces the expression of arginase 1 and vascular endothelial growth factor (VEGF) in macrophages via HIF-1 stabilization, promoting tissue remodeling and angiogenesis while dampening anti-tumor immunity (140)

One week administration of 10 mg/kg of melatonin significantly increases SOD activity in rat hepatocytes [60], while some reports show enhancement of SOD activity in rat kidney, liver and brain after a single melatonin injection (5 mg/kg) [61]