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Rasmussen J, Dun?M, Lund AM, et al

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In addition, in human organoid cultures but not in mouse organoids or 2D cultures, neuromelanin-like granules were found accumulating in DA neurons over time ( In conclusion, the current human iPSC differentiation protocols provide consistent degree of fidelity with the original in vivo DA neuron phenotypes, generally higher in 3D organoids vs

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[70] Fisher JS, Gao J, Han DH, Holloszy JO, Nolte LA.Am J Physiol Endocrinol Metab