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Concurrently, macrophage and fibroblast activity has been observed, placing it among compounds investigated in relation to tissue regeneration

Another element that plays a role in myelopathies caused by B12 deficiency is the disturbance of neuronal lipid and protein synthesis, which includes fundamental elements such as myelin proteins that create myelin sheaths in the spinal cord and peripheral nervous system (PNS) [83]

FIGURE 1 Bacillus amyloliquefaciens (PDB ID: 1BNR) (Bycroft et al., 1991), and X-ray crystal structure of isopenicillin N synthase (IPNS) from Emericella nidulans (strain FGSC A4/ATCC 38163/CBS 112.46/NRRL 194/M139) (PDB ID: 1QJF) (Burzlaff et al., 1999)