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Clinical Studies Efficacy for PROZAC was established for the: Acute and maintenance treatment of Major Depressive Disorder in adults, and children and adolescents (8 to 18 years) in 7 short-term and 2 long-term, placebo-controlled trials [see Clinical Studies 14.1]

cGAS, a cytoplasmic double-stranded DNA (dsDNA) sensor protein, catalyzes the formation of cGAMP (160)

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43 Alternatively, LAP can also form disulfide linkage with leucine-rich repeat-containing protein 32 (LRRC32) or LRRC33 to tether SLC to the cell surface