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Clinical evidence supports these anti-inflammatory effects

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Metcalf C.A., Duffy K.A., Page C.E., Novick A.M

J Thorac Cardiovasc Surg 132(6):1488-9, 2006

For example, when an injectable and pH-sensitive peptide hydrogel loaded with methotrexate and bismuthene nanosheet/polyethyleneimine (BiNS/PEI) reduced macrophage cytokine secretion and eliminated synovial fibroblasts, a multi-target therapeutic effect was achieved (104)