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They are especially redox sensitive since their Cys side chains must cycle between and free disulfide forms

These compounds also suppressed NF-B activation and mitogen-activated protein kinases phosphorylation (extracellular signal-regulated kinases 1 and 2 (Erk 1/2), and c-Jun N-terminal kinase)

Many classes have been recognized so far, some of them with multiple members which may share sequence identities around 40%

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