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PROVEAN yielded very poor correlations of = 0.44 ( p = 0.27), 0.59 ( p = 0.09), and 0.64 ( p = 0.05) for age of onset, disease severity, and clinical vitamin B 6 response, respectively

This is usually a gradual, subtle shift rather than a dramatic change

IGF-I is a polypeptide that belongs to the family of insulin-like growth factors similar in molecular structure to proinsulin and is a synthetic analog of insulin-like growth factor 1 (IGF-I