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Subsequently, in the progression phase, the reduced levels of glutathione and decreased GPX4 activity prevent the timely reduction of lipid peroxides, exacerbating lipid peroxidation reactions and generating a large amount of lipid reactive oxygen species (ROS)

Hua S, et al

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Also, IFN- (along with IL6 and TNF-) promotes iron uptake by the macrophages [126], thereby restricting iron availability to the developing erythrocytes

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