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This carboxylationdecarboxylation sequence is crucial, as it facilitates the formation of PEP by making the reaction energetically favorable

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their role in tumorigenesis, metastasis, prognosis and therapy

In contrast, chromatin immunoprecipitation assays revealed that genistein significantly enhanced acetylation of histone H3 at the DKK1 promoter in both SW480 and HCT15 cells