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Suppressors of trxB gor are a triplet repeat expansion of ahpC to ahpC*, and in these strains an alkyl hydroxyperoxidase is converted to a disulfide reductase

This technology can accurately predict the interaction forces (such as hydrogen bonds and hydrophobic interactions) between small molecule compounds and the active pockets of target proteins, accurately obtain binding conformations and binding energy data, and provide direct guidance for subsequent structural optimization

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doi: 10.1007/82_2018_117 73 KeY.LiD.ZhaoM.LiuC.LiuJ.ZengA.et al

In a subgroup analysis of patients with HCC beyond the up-to-seven criteria, the median PFS times in the Atezo/Bev (n=134) and LEN (n=117) groups were 10.5 months (95% CI, 7.011.8) and 6.3 months (95% CI, 5.57.3), respectively (p=0.044)