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Here, astrocytes and Mller cells transfer lipids to retinal ganglion cells for synapse formation and axon maintenance, and photoreceptors for maintaining their highly membranous outer segments ( 3.4 Glutamate The main neurotransmitter released by presynaptic neurons in the vertical pathways through the retina is glutamate ( 4 Glial metabolic changes in glaucoma Inflammation in glaucoma is now well-established in animal models and humans

J Pharmacol Exp Ther 338:537547 Cheah IK, Ng LT, Ng LF, Lam VY, Gruber J, Huang CYW, Goh FQ, Lim KHC, Halliwell B (2019) Inhibition of amyloid-induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model

10,278 Genetic suppression of the IKK/NF-B pathway, achieved through the deletion of one p65 allele, or pharmacological intervention via IKK inhibitors, such as 8K-NBD, has been shown to delay the onset and mitigate the severity of aging symptoms and age-related pathologies in the nervous system of murine models 10,279