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Depletion of NAD+ in alcohol metabolism, resulting in a lower NAD+/NADH ratio, has been suggested to be a contributing factor in alcohol toxicity (Cederbaum 2012)

Activation of Nrf2 by either cellular redox status or pharmacological intervention leads to the up-regulation of over 250 genes encoding proteins that are involved in antioxidant defense systems, redox homeostasis, and xenobiotic detoxification [81]

Other antioxidants According to the key role of oxidative stress in the pathogenesis of DE, many antioxidants targeting ROS production have shown the potential of DE treatment

Together, these integrative strategies illustrate how carefully designed combinationsspanning autophagy restoration, ferroptosis inhibition, pyroptosis restraint, antioxidant activation, and regenerative supportcan disrupt self-amplifying microglial death programs and improve neuronal outcomes

PLOS ONE 11 , e0146931 (2016)