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However, it is estimated that up to 25% of type 2 diabetic patients suffer paraesthesia, described as a prickling and tingling sensation, hyperesthesia or overt pain described as burning, sharp, electric shock-like and lancinating.2 Untreated pain often leads to significant disability, such as reduced physical activity, poor sleep quality, and worsening anxiety and depression.3 These complications can lead to significant financial burdens on patients and the healthcare system

Int J Immunopathol Pharmacol

Monitoring for any immediate reactions

These effects are particularly noticeable in individuals with a B12 deficiency or conditions like chronic fatigue syndrome or anemia, where long-term treatment can significantly improve quality of life

Instead, they suggest that under some chronic neurodegenerative conditions, the BBB may maintain its structural and functional integrity