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[DOI] [PMC free article] [PubMed] [Google Scholar] 99.Strong E., Butcher D.T., Singhania R., Mervis C.B., Morris C.A., De Carvalho D., Weksberg R., Osborne L.R

In addition, the treatment of nicotinamide (NAM), a form of vitamin B3, suppressed the activity of sirtuin-1 (SIRT1), a regulator of cellular stress resistance, and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), a key transcriptional coactivator involved in mitochondrial biogenesis and energy metabolism

This effect is associated with inhibited oncogenic activity of AKT and MYC, as well as Bax phosphorylation, suggesting that PP2A may also be a potential metformin target in lung cancer therapy

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