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Brain derived neurotrophic factor in newly diagnosed diabetes and prediabetes

Carr MT, Ferri A, Cozzolino M, Calabrese L, Rotilio G

By binding to NRF2 and suppressing its canonical transcriptional ability to regulate cellular redox balance, mut-p53 directly decreases GSH reserves and increases basal ROS levels, thereby predisposing cancer cells to further oxidative stress (Fig