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However, high doses (a single intraperitoneal injection of 250 mg/kg) of FA can also cause AKI in mice, and continuous injection can cause AKI to convert to chronic kidney disease (CKD) in mice 347

An allergic reaction, by contrast, may involve itching that spreads beyond the injection site, welts or hives appearing on your arms or chest, swelling that worsens after 12 hours, or warmth and redness extending more than 2 inches from the injection point

GH and IGF-1 are related but not identical: GH has stronger direct effects on fat metabolism, while IGF-1 is more directly linked to tissue growth and repair signaling