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Despite the widespread use of levothyroxine replacement therapy, a substantial proportion of patients continue to experience persistent symptoms and metabolic dysregulation even after achieving biochemical euthyroidism

Among these, mesenchymal stem cells (MSCs) have become the most promising therapeutic tools due to their self-renewal, multilineage differentiation potential, low immunogenicity, and immunomodulatory properties (Ogaili et al., 2025)

Side effects are rare but may include mild redness or swelling at the injection site

High levels of estrogen, especially that of estradiol, before the menopause may be involved in the high energy capacity as well as the control of redox balance in female brain (Figure 1)

Muscle Injury and Recovery Research Studies on component peptides in muscle injury models revealed complementary healing mechanisms: BPC-157 showed faster restoration of muscle architecture in crush injury models TB-500 enhanced satellite cell activation and myofiber regeneration GHK-Cu improved collagen content and reduced fibrosis formation Combined mechanisms suggest enhanced functional recovery potential Bone and Cartilage Research Investigations in fracture and cartilage models demonstrated effects on bone repair processes, including improved callus formation and mineralization in animal studies