glutathione increase platinum drugs Frontiers The resurgence of platinum-based cancer

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The first and most immediate consequence is a catastrophic loss of potency

In response to oxidative stress, neurons undergo overactivation of the enzyme poly (ADP-ribose) polymerase-1 (PARP1) to prevent DNA damage, which decreases intracellular NAD and ATP levels, compromising the efficiency of glycolysis and oxidative phosphorylation, affecting the ability of neurons to generate ATP (200, 203)

Possible Side Effects of Glutathione IV Therapy Some individuals may experience temporary side effects, such as: Allergic reactions (in rare cases) Headaches Nausea Abdominal cramps Changes in blood pressure It is crucial to discuss any pre-existing medical conditions and concerns with a healthcare provider to ensure the safe administration of this therapy

On the other hand, NAC shows stronger reactivity towards hypochlorite and nitrogen dioxide, partially explaining its direct antioxidant effects against exogenous factors like diet, air pollution, or certain inflammatory conditions (Meyer et al., 1994