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Moreover, vascular normalization can also improve oxygen supply to tumor tissues, mitigating the effects of hypoxia, which often renders cancer cells more resistant to treatment (36)

The limited absorption of the nasal cavity restricts the amount of drug being effectively absorbed, making class I drugs (high permeability, high solubility), according to the Biopharmaceutics Drug Disposition Classification System (BDDCS), particularly suitable for nasal delivery (Ugwoke et al., 2001)

Synthesis of bile acids from cholesterol occurs in the hepatocytes, and pericentral hepatocytes are believed to be most active in this regard

PMID 11454918