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It was included as a tertiary agent in the 2017 edition of the multi-agency clinical guidelines for the treatment of hypertension (Whelton et al, 2018), but was no longer mentioned in the 2025 AHA/ACC multisociety hypertension guidelines (Jones et al, 2025)

The detailed clinical information is tabulated in Supplementary Table S1

doi: 10.1186/s13018-023-03855-w 44

Their mechanistic alignment with both endocrine and redox axes positions MI as a cornerstone in integrative strategies targeting the redox-endocrine-metabolic triad central to PCOS pathophysiology