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However, its half-life in the bloodstream is remarkably short, around 15 minutes, due to rapid degradation by aminopeptidase enzymes

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These conditions may also coincide with nutritional deficiencies, particularly of cysteine and glycine, which are required for glutathione synthesis, further impairing the cycle and promoting diversion toward PGA production [70, 71]

doi: 10.3390/nu14010231 61 SalarolliRTAlvarengaLCardozoLTeixeiraKTRdeSGMLLimaJDet al

Capsaicin increases the generation of lipid peroxidation products in vitro but not in vivo , and this response is blocked by receptor antagonist capsazepine (Leonelli et al., 2010)