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Accumulated SAICA riboside is thought to be the primary neurotoxicant involved in this disorder, based on animal models (79)

The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones

Serum folate reflects short-term changes in diet and may be altered by recent meals, so fasting for about six hours beforehand is required, and repeated testing is needed to identify true deficiency

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In direct comparisons of ALC with active drugs, ALC had fewer reported AEs, mostly CNS or GI, while comparator events reflected drug-specific profiles (eg., endocrine events with amisulpride)