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These include dysregulated iron metabolism, phospholipid remodeling, antioxidant system failure, mitochondrial and lysosomal dysfunction, and persistent SASP-mediated inflammatory signaling (Figure 2) (Tang et al., 2025

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SARS-CoV-2 infection triggers oxidative stress Physiological concentrations of reactive oxygen species (ROS) are essential for normal immune regulation

Virulence 5 , 2026 (2014)