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In vivo photothermal and antitumor experiments confirmed that the material can generate large amounts of heat and ROS, leading to apoptosis and tumor-growth restriction

Influenza a virus and TLR7 activation potentiate NOX2 oxidase-dependent ROS production in macrophages

Genistein protects against acute pancreatitis via activation of an apoptotic pathway mediated through endoplasmic reticulum stress in rats

doi: 10.3389/fphar.2026.1694895 Received 29 August 2025 Revised 30 November 2025 Accepted 12 January 2026 Published 13 February 2026 Volume 17 - 2026 Edited by Ji Yichun, University of California, San Diego, United States Reviewed by Janina P

These factors frequently cause neurons to be under stress, which in turn causes cytotoxic events such as an increase in excitotoxicity, ROS, synaptic dysfunction, ER stress, impaired protein degradation systems, DNA damage, cell cycle re-entry, inflammation, and mitochondrial dysfunction (Seward et al., 2013)