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Additionally, activated microglia contribute to oxidative stress through the release of ROS, NO, and pro-inflammatory cytokines such as TNF-, IL-6, and IL-1, inducing motor neuron death [254]

Watch NBC 5 free wherever you are CEO Lars Fruergaard Jrgensen on Thursday acknowledged the sharp share price reaction after two consecutive late-stage trials showed underwhelming weight reduction versus the company's own targets, but said he nevertheless remained "encouraged" by the drug's weight loss profile