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Description

We also describe pharmacological challenges in the design of isoform-selective activators or inhibitors for AC5 and AC6, which may be relevant to developing new therapeutic approaches for several cardiovascular diseases

The up-regulated Orn levels and Orn/Cit ratio indicated the disordered urea cycle in AHU and gout, which subsequently influence oxidation stress

Currently a new generation of NOX inhibitors is being developed

Actin and Ponceau S staining were used as loading controls

As recently described (Le et al , 2020), CEST2.2 localizes to intestinal granules and contributes to the biosynthesis of ascarosides, including ascr#8, ascr#81, and ascr#82