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Orphanet J Rare Dis 16 , 295 (2021)

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Curry 1 , (1)Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, (2)University of Iowa Hospitals and Clinics, (3)University of Texas Southwestern Medical Center, (4)Mallinckrodt Pharmaceuticals, Bridgewater, NJ Background: Hepatorenal syndrome type 1 (HRS-1) is a rapidly progressive form of renal failure associated with high mortality in patients (pts) with decompensated cirrhosis and ascites

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on cynomolgus monkeys (25 males and 25 females, aged 35 years) utilizing rotigotine behenate-loaded PLGA microspheres (rotigotine loading of 56.256.7%) as a long-acting dopamine agonist formulation for the treatment of PD through continuous dopaminergic stimulation 138