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Having into account the heterogeneity of the fibroid presenting patient population, the confounding evidence about fibroid effect on reproductive outcome and its relationship with assisted reproductive techniques for infertility treatment, the therapeutic decisions should be based on personalized and patient specific considerations

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For example, a recent systematic review and meta-analysis of Ginkgo biloba in depressive patients reported overall efficacy on depression rating scales and related biomarkers but did not stratify outcomes by subtype such as post-stroke, postpartum, or depression comorbid with medical illness, nor was evidence on subtype-specific effects identified in the analyzed trials (103)

ROS can further activate epithelial cells and macrophages facilitating neutrophil, monocyte, and lymphocyte recruitment, and the recruited activated inflammatory cells subsequently enhance additional ROS generation, increasing the pro-oxidant burden (8085)

doi: 10.1111/epi.12461 201