foxo4-dri senolytic 2023 2024 induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation Senotherapy for chronic lung disease
Senotherapy for chronic lung disease ScienceDirect Senolytic Peptide FOXO4 DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes PMC foxo4 dri peptide senolytic 2023 2024 study FOXO4 DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53 serine 15 phosphorylation The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications Full article: Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics
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