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Figure 9 MSH functions as a cofactor for many redox enzymes that are involved in the detoxification of peroxides, electrophiles (formaldehyde), NO, aromatic compounds (maleylpyruvate) and arsenate (Fahey, 2013) (Table 1)

It also contributes to the regulation of glucose metabolism, helping to keep blood sugar levels in balance

However, during inflammatory condition where there is a high demand to consume NADPH, G6PD is released from its inhibition and forms an active homodimer (51, 52)

The monitoring of GSH/GSSG ratio and the quantification of GSSG in biological samples are essential for evaluating the redox and detoxification status of cells and tissues in relation to the protective role of glutathione against oxidative and free-radical-mediated cell injury