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Nociceptive neurons are endowed with a series of receptors, such as innate immune system receptors, like Toll-like receptors (TLR), which can directly detect the presence of a pathogen and send danger signals to the immune system, for instance through the secretion of neuropeptides that activate immune cells

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Lapelusa, M, Qiao, W, Iorgulescu, B, San Lucas, FA, Patel, KP, Bhamidipati, D, Thomas, J, You, YN, Foo, WC, Maru, D, Thirumurthi, S, Morris, VK, Kopetz, S , Overman, MJ, Ludford, K

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doi: 10.1016/j.bbrc.2016.08.034 149 ZhangY