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Experimental studies in islet transplantation and thrombosis models demonstrate that BL exerts anti-ferroptotic effects through multiple mechanisms, including upregulation of HO-1/Nrf2 signaling, enhancement of cellular viability, elevation of antioxidant capacity, and reduction of cell death (Yao et al., 2020a,b)

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Studies indicate that individuals with lower B12 levels are more likely to be obese[2], even after accounting for factors like diet, lifestyle and medication use

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These findings support the conclusion that R-loop-mediated fork stalling induced by oncogenic RAS is a consequence of ROS-induced dissociation of the TIMELESS-TIPIN complex from the replisome, which slows down replication fork progression