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Figure 1 The Glycolytic Pathway In macrophages, glucose from the extracellular environment typically enters the cell through the glucose transporter GLUT1 (Glucose transporter 1) [encoded by the gene Slc2a1 ( Solute Carrier 2a1)] to fulfill glycolysis ( Figure 1 )

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Imaging in patients with manganese-related movement disorders Due to the paramagnetic properties of Mn, its deposition in the pallidum is detected as hyperintensities in the globus pallidus on magnetic resonance imaging (MRI) and is a characteristic MRI finding in the brain [39]

Astrocytes overexpressing mSOD1 release soluble factors that trigger degeneration of motor neurons, with motor neurons overexpressing mSOD1 being particularly vulnerable