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[17] Evidence suggests that IGF-IR signaling is required for survival and growth when prostate cancer cells progress to androgen independence

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Similar to other -lactams, ceftolozane inhibits PBP (PBP1b, PBP1c, and PBP3), enhances outer membrane permeability, increases stability against efflux, and enhances stability against chromosomal AmpC -lactamase, which prevents the production of bacterial cell walls and causes cell death ( Figure 3 ) (Perovic et al., 2023)