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However, lower systemic exposure from oral delivery is not automatically "safer," since under-dosed compounds may still carry unknown long-term risks without providing benefit

As illustrated in Figure 1, genetically determined increased levels of TLR2 (rs1816702) and MD-2 ( LY96 ) (rs11465996) (required for TLR2 and TLR4 to respond to LPS) 15, 16 were associated with beneficial response among patients with CD, indicating that a higher activity of TLR2 was associated with a beneficial response among patients with CD

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