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Samples were exposed to H2O2 in a 37C incubator for 2 hours and then were evaluated

The authors called the lowered 24-h urine iodine output of ME/CFS patients remarkable (which may simply mean notable)

Mitochondrial permeability disrupts the ion gradients across the inner mitochondrial membrane, resulting in mitochondrial depolarization, a loss of oxidative phosphorylation, and an increase in ROS production (Garca-Ruiz et al., 1997)

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Additionally, it can hinder skin pigmentation by impacting the tyrosinase activity of skin cells and curbing the creation of melanin