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Reduced acinar cell replacement is likely due to decreased cell proliferation rather than cell death as we measured a reduction in Ccnd1 , while markers of cell death [activated caspase3 (CASP3 + ) cells in Fig EV3G or Bax, Pmaip1 (NOXA) and Bbc3 (PUMA) in Fig EV3H)] were either not observed or remained unchanged

tau knockout mice (Mapt0/0)

The half-life of survodutide is approximately 109 to 115 hours, or roughly five days

Funding This research was funded by the European UnionNext Generation EUunder the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 -M4 C2, Investment 1.5-Call for Tender No