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Our present understanding about the stress signaling in plants is that the changes of GSH/GSSG, following the synthesis of H2O2, constitute an early stress signal leading to the physiological response, usually activation of antioxidant mechanisms or modification of gene expression (Trewavas and Malh, 1997)

In addition, fisetin inhibited the activation of the NF-B signaling pathway in BEAS-2B cells stimulated by TNF-, reducing phosphorylation of IB- and nuclear translocation of p65