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doi: 10.1038/nm1511 230 LuoZLiMWuYMengZMartinLZhangLet al

Please Note: Treatment is subject to consultation

ACSL4-driven ferroptosis involves the downstream molecule GPX4, which is essential for inhibiting ferroptosis by eliminating phospholipid hydroperoxides [33]

extremely unstable metabolites may bind covalently to and inactivate the enzyme that forms them, whereas more stable species may be able to diffuse to a distant site, for example DNA, and initiate changes such as cancer