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Blood 124 (1), 134141

One major route is the kynurenine pathway, which produces metabolites involved in immune regulation and neuroactive signaling

Biochim Biophys Acta 1862:651661

But for the vast majority of patients living with chronic autoimmune disease, standard care alone rarely produces lasting improvement

e , f , Normalized XKR8 gene expression in human ( e ) or mouse ( f ) immune cell subsets, analyzed using data from the Human Protein Atlas (HPA) and Immunological Genome Project (ImmGen), respectively