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Theranostics 11 , 85708586 (2021)

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These endogenous danger signals activate innate immune pathways in resident renal cells and infiltrating leukocytes, thereby amplifying inflammatory cascades and perpetuating tissue injury (Bonventre and Zuk 2004

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Since gout is directly related to uric acid levels in the blood, these risk factors are primarily associated with the production and excretion of uric acid: Diet: Foods such as red meat, certain seafoods (i.e., shrimp and oily fish), alcoholic beverages (especially beer), sugar, and fructose (often found in soft drinks) can all increase uric acid levels